A Chicago-based biotech venture capital firm, Portal Innovations, plans to launch operations early next year inside the former Boston Globe headquarters at 135 Morrissey Blvd.

The firm, which says it specializes in “early-stage life sciences venture creation and investments” plans to take up 22,000 square feet of space, and then expand to 58,000 square feet in the first half of 2024.

Portal Innovations will be partnering with another company, ZoE Life Sciences, and Beacon Capital Partners, the real estate investment firm that is part of the ownership team behind the revamp of the former Globe headquarters, on building out the space.

“Boston is home to world-class universities, premier life sciences venture capital firms, and an unsurpassed pool of diverse talent,” John Flavin, founder and CEO of Portal Innovations, said in a statement. “Portal is eager to support entrepreneurs and founders by providing its Crafted Capital model of seed capital investment, access to strategic lab space, and management expertise to de-risk these early-stage ventures.”

Fred Seigel, CEO of Beacon Capital, said the former Globe headquarters offers a “fully developed life sciences ecosystem in a single building that will catalyze the next phase of Boston’s impact on life sciences.”

The entire building, rebranded as “Southline Boston,” spans 700,000 square feet, and includes a food hall, gym, roof deck, and a brew pub.

Nobull, a fitness apparel company, is another tenant at the property., as is Flagship Pioneering, a venture capital firm.